Do it right
Audio is special. Use shielded wire and the shielding wire is active part of the audio circuit and is connected at both ends. It is an actual ground for the audio circuit. At one end is the source or output (radio, mic or headphone/speaker). At the other is ground to the intercom.
In general the plugs should (must, better do it or you will have noise?) be isolated from the airframe. The Mic and Phone plugs used three wire and two wire respectively. The Mic has hot, gnd and ptt, so a two conductor shield with insulation is ideal, ACS sells it. For the phone/speaker, a single conductor shielded with insulation works nicely. You can get a single three conductor with shield for both. I prefer to run two cables out to each plug, mic/phone.
With this concept the PLUGS ARE ISOLATED (insulated) from the airframe with plastic shoulder washers or mounted on a non conductive surface. In both cases, the shield is grounded at plug and at intercom/radio.
Some models of intercoms have separate grounds for each circuit input (mic, phone, aux input & Com radio). Some intercoms don't provide a PIN for a ground for each input/output, so you have to daisy chain or gang the grounds together at the intercom and ground them to the single ground provided, which could be the power ground.
THE KEYS ARE: CENTRAL GROUND AND SHIELDED WIRES.
Audio is measured in millivolts. Long wires make nice antennas. Now run that wire to an amplifier (intercom) and poof, radio receiver. If the wire is the right length, it can "resonate" at the frequency of local RFI or EMI. RFI and EMI are basically the same thing. One is produced by a radio, one is a radio signal not made by a radio, but the noise affect is as undesirable regardless. The physics are the same. Radio waves are non ionizing magnetic radiation. If you get radio waves in ultra higher freqs, it becomes microwave and x-rays, which is harmful. Any way we digress (again).
Shielding is the key to keeping your audio wires from becoming radio receiver antennas.
Non audio wires that can become transmitters (like your Com's coax) must be shielded at both ends.
The quick & dirty way is to not use separate grounds, just local airframe grounds where convenient, the shotgun approach. That works for many things but NOT AUDIO EVER. YOU ARE ASKING FOR NOISE. That is my opinion and from experience it seems about right. It is very attractive to save wiring, Using shielded wire and many ground connections at the intercom and each jack connection is a pain, but worth it. Shield braid itself is hard to handle and you have to solder on a short pig tail. With that said, if you go quick and dirty by all means twist the wire pairs together and route them away from any thing making RFI or EMI (which is impossible).