The Dynon intercom does not integrate with the Skyview system in any special way. It does match their other modules, which is why they made it, for a more aesthetically pleasing panel.
The Dynon COM does integrate with their system for great features with the extra buttons on the COM Panel. If the Skyview system fails you can still use the COM, but settings like squelch, mic gain, etc are set by the screen. If you wanted to adjust these settings, you would have to connect the COM to a Skyview system to make the adjustments. I assume they are either saved in the transceiver or the COM panel, so they may stay when going back to a non-Skyview panel, but I'm not sure.