The Honda V6, while it redlines at 6000-6500 (I'm too lazy to go to my garage and check) may have been tested to run at 5000 rpm for several hundred hours was not DESIGNED to operate at that level. It was designed to run between 800-4000 rpm on a regular basis. That testing is designed to determine a break point in the engine...remember that. So what you are saying is that you are comfortable running an engine on a regular basis at an RPM the manufacturer utilized to test for failure points. If you insist on running the engine at its limit your margin for failure has just gotten a lot smaller in my opinion. Having said that, I do agree that most auto conversions fail between the engine and the prop, not necessarily in the engine itself. So what is the answer...I don't know
Yup, they are designed to operate at at full power/ full rpm without failure and tested as such for hundreds of hours. I think I already said that.
They are OPTIMIZED to run at 800-4500 rpm. Engine redlines are set to meet performance standards and by careful engineering studies into the stresses and strength margins of all the parts. Engines are rarely tested to destruction on a widespread basis.
Yes, I'm comfortable operating auto engines at or near power peak rpm for takeoff because for over 25 years, I built street, performance and road racing engines for a living and understand the testing that goes into these designs and the stresses involved. Most Japanese designs have considerable margin and I've related some stories of Showroom Stock engines going hundreds of hours between overhauls on these pages previously while being flogged past redline on every shift, specifically Toyota 4AGE engines.
In any case, we generally do not operate aircraft engines at full rated power for very long either since aircraft don't spend much time at sea level or max rpm. It is no different with auto engines in aircraft. We might use 5000-5500 rpm for takeoff and between 4000 and 4800 for cruise typically. (I cruise at 4600 rpm usually).
The Honda J35 series will produce 180hp at only 4200-4800 rpm depending on version so in an RV6-8, you would not be stressing the engine at all. It's unlikely you'd be cruising at over 4000 rpm. Piston speeds are well within acceptable ranges at these rpms for good longevity.
The fact that many designs can run 10-20% over redline and be turbocharged to produce double or triple the factory hp output with no or minimal internal changes is testament to the very large strength/ design margins in these designs. Operating continuously at 55% of rated power in this case to match O-360 cruise hp is really nothing and routinely done on the marine versions of these engines and cruising on the Autobahn in Germany.
As Paul stated, the automotive core engine reliability is rarely a problem (assuming lay people don't mess with factory engineering), the problems relating to power loss are usually attributed to fuel, spark, cooling or gearbox issues. These need to be addressed with proper design and testing.