I do fly several Angel Flights a year. Sometimes I'm just "in the mood" to do something good, sometimes I'm taking a trip empty somewhere and it doesn't cost me anything to take someone with me. Every Angel Flight I do is tax deductible, too.
I'm in California and Angel Flight West does not allow experimentals. There are other region around the country that do allow experimentals and even LSAs. Check with your local wing.
I have done several Angel Flights on IFR flight plans, in IMC. Again, this might vary by what region you are in, but our wing does not require an IFR rating, only 250 hours total time and liability insurance. An IFR rating is very helpful since many flights have to be cancelled at the last minute if you don't have it. Of course, I've cancelled a couple of IFR flights because I just didn't like the weather.
It's a very worthwhile organization and I love supporting it. Check with your local group and see what their requirements are. It's very rewarding.