I have struggled with this, and continue to do so. I really want to fall in love with something other than Garmin, especially since I think that the others are more likely to give me options like a real HUD someday, but it's hard to do. When I price out my IFR panel, Dynon comes in a little more than Garmin and with less convenience of use.
I am planning to have a G3X Touch system with a 10.6" MFD on the right side, 10.6" PFD with SiriusXM on the left side, a secondary ADAHRS, two-axis autopilot (I'm still torn on yaw damper in this plane), a G5 backup instrument, heated/regulated pitot tube, GTX 45R transponder, GTR 20 remote radio, GMA 245 audio panel (nice to have real knobs for quick volume adjustments when passenger talks too loud into the mic), and a GTN 650 navigator. With this setup, I can plan my flight on my iPad, get into the plane, transfer from the iPad to the GTN 650, and fly my plan almost entirely from the PFD, including changing radio and transponder settings on the way.
If things start to fail, there is a backup for nearly everything in the plane that will automatically get the data it needs from other sources before they fail. For example, I believe that my altimeter setting in the G3X will propagate to the G5. Less stuff to keep me busy means more brain power for other tasks and less chance of forgetting to set the backup instruments up and only finding my mistake when the PFD and MFD both fail and the backup instrument takes me directly into a mountainside.
With other manufacturers, there is bound to be less integration and thus more workload to keep everything in sync. I am still a long way out from spending actual money to buy actual avionics, so I will keep trying to change my mind. I am excited to go to Oshkosh this year and let the professionals try to help change my mind, too. I just can't at this point see myself paying more money for less integration in the cockpit.