I just did the same thing (first long cross country) and DID experiment. I went from 2650 all the way down to 2350 (21 inches, 50 LOP) and found that at 9500, the difference between them was about 3 kts and nearly 1 GPH. So I stuck with 2350. 180 KTAS on 8.6GPH isn't too bad!
Anyway, I have it written down - will post up later.
EDIT: From my notes:
9500 ft, 29.97, 59 degrees OAT, WOT (21.0 MP), 45 LOP-
2550 RPM = 153 KIAS, 9.1 GPH
2500 RPM = 153 KIAS, 8.9 GPH
2450 RPM = 150 KIAS, 8.7 GPH
2380 RPM = 149 KIAS, 8.5 GPH