I have a SkyView with the ICOM 210.
They work very well together. Note, I have a Sigtronics 200S intercom, which works very well.
All my audio alarms go through the ICOM and then to my intercom. The combination works out very well.
Correction, I have the 210, not the 220. My understanding is the 220 is an upgraded version of the 210. If that is the case, i would have no issues with going with another ICOM radio.