North to Alaska
Yes, as noted above, the biggest challenge you may encounter is dealing with US customs & EAPIS procedures on both sides. Do your research ahead of time!
I should mention that Canada has very different gun laws, so know this before hand by inquiring with Canada customs in advance.
Your routing suggests a fairly straight forward course following the AlCan highway (we just call it the Alaska Highway), which winds NW through Calgary, Edmonton, Grande Prairie, Ft Nelson, Watson Lake, Whitehorse, than on to Alaska. These communities all have good airports, accomodations, etc., & are mostly generally spaced right for fuel stops. Wide open flying all the way up to Grande Prairie, than graduates to wide valley flying with a few passes along the way beyond. Fantastic scenery all the way.
Think of flying in Canada as what it was like to fly in the US 10 years ago. Nexrad ends just south of Grande Prairie, you can still get Metars / Area forcasts & such from NavCanada on their area FIS frequencies farther north. These frequencies change from area to area & usually listed in Airport Comm listings. Flight Following will disappear about Edmonton. There is a common VFR frequency of 126.7 used for pireps, position reports, & weather alerts. It is strongly advised to file Flight Plans with NavCanda, 1-866-992-7433, they are usually automatically opened but you are responsible to close them. Flying in a group you could suffice with flying on Flight Itineries as long as all know how to activate emergency services if needed.
Along with other resources mentioned, you could also check out:
http://www.copanational.org/TransborderOps.cfm
Sounds like you are passing thru on this trip, maybe next time you could make Canada your destination, explore your northern neighbor. We have a huge, wide open land mass to get lost in! Think- less than 1% being MOAs, & NO TFRs! & Canadian Beer!